St. Jude Medical Center is a faith-based, not-for-profit hospital,[1] located in Fullerton, California, which was established by the Sisters of St. Joseph of Orange in 1957.

[2] Part of the St. Joseph Health System, St. Jude Medical Center serves as a quaternary and referral center for a variety of patient services, including one of California's only accredited programs in spinal cord injury, brain injury, and comprehensive stroke rehabilitation.

The Sisters of St. Joseph of Carondelet began operating their first hospital in Eureka, California in 1919 in response to the Spanish Flu epidemic.

[5] They acquired Fullerton General Hospital, a historic facility designed by Frederick Eley,[6] in 1931, but it did not meet postwar standards for operation.

A businessman, Miles Sharkey, donated land in western Fullerton with the stipulation that it be used to build a hospital.