[4] Originally a 6-bed facility in a converted 2-story house at the corner of 1st and Bannock Streets, the hospital immediately began to expand with construction of a contagious disease annex.

[6] In 1903 plans for a new, larger hospital were drawn by the architecture firm of Tourtellotte & Co.[7] Completed and opened late in 1903, the new St. Luke's was a 3-story, brick and stone building capable of treating 25 patients, with sleeping quarters for nurses and a nurses training school.

The hospital also made plans to demolish its original building, the converted house,[9] and St. Luke's graduated its first class of nurses at the training school.

[17] By 1970 a shortage of hospital beds and crowded facilities prompted St. Luke's to consider another expansion.

[21] In 1993 St. Luke's opened the first 4-stories of its 10-story tower that now defines the hospital skyline at N 1st and Bannock Sts.

[25] The project proposal became part of a larger expansion plan in 2014 that includes a new building with 60 beds, laboratory space, and cardiac care facilities north of E Jefferson St., directly behind the existing hospital.

[28] In 2017 a 98-foot giant sequoia, planted in 1912, was moved from the hospital grounds to provide space for construction.