The hospital's foundation was laid on 5 April 1930 by the Governor of Malta, John Du Cane, in the presence of then Prime Minister, Gerald Strickland.

[1] Progress in the construction of the hospital was slow due to technical difficulties encountered.

By 1939, at the onset of the Second World War, the hospital was still incomplete and the work was suspended.

The hospital building is included in the National Inventory of the Cultural Property of the Maltese Islands.

[2] The Hospital served students attending Medical and Health Sciences courses within the University of Malta.