[1] Opened in 1952, the hospital was founded by the Cancer Association of Ireland on the recommendation of a consultative body set in place by the Minister for Health.

[3] He was awarded the RIAI Triennial Gold Medal for the period 1950–52 by the Royal Institute of the Architects of Ireland for his design of St. Luke's Hospital.

[4] Following the publication of a report by Professor Donal Hollywood entitled "The Development of Radiation Oncology Services in Ireland" in 2003,[5] the Department of Health and Children decided to create cancer treatment centres of excellence in the Beaumont Hospital and St. James's Hospital.

St Luke's Radiation Oncology Network (SLRON) Radiotherapy centres were built within the grounds of the Beaumont Hospital and St James's Hospital and operate as part of a three site network.

[8] Mary Harney subsequently clarified, that even after oncology services were transferred, St. Luke's Hospital would be retained as a public health facility.