Saint Mark's Roman Catholic Church (Greek: Ιερός Ναός Αγίου Μάρκου) is located on the St. Mark square in the city of Zakynthos, Greece, and holds the distinction of being the only Catholic church on the island with this name.

In the 1960s, the church was rebuilt in its current form, maintaining much of its original exterior appearance.

Near the church stood a building containing a large library and a photo gallery, both of which were also lost in the great fire that followed the earthquake.

[2] The current church preserves a few remaining artifacts from the original structure, including the statue of Saint Mark, two large candlesticks flanking the statue's pedestal, the Holy Cross, a small marble baptismal font, and other smaller objects.

The 1994 renovation of the church included updates to the floor, the altar, the statue pedestal, the base of the monstrance containing the Eucharist, the pulpit, lighting, and various pieces of furniture.