It was established in 1353 together with the adjacent Augustinians cloister and a hospital of the Holy Spirit intra muros by Siemowit III duke of Masovia and his wife Eufemia.

The main façade of waved lines represent so-called Melted Sugar style in rococo architecture.

The central altar was also changed according to Karol Bay's design with sculptures by Jan Jerzy Plersch in 1751.

The profuse early baroque furnishings, created in the 1630s by Jan Henel (sculptor of King Władysław IV Vasa) together with the rococo decorations done in the 1750s, were destroyed by German bombing during the Warsaw Uprising.

[2] Next to the sanctuary there is a chapel of St. Francis with the most valuable element of the church's furnishing - a polychromed figure of the Virgin Mary with the Child.