It operated as a train station from 1858 until 1941, and remained in service for non-passenger functions until the 1970s.

Since December 2020 the station is home to an independent micro brewery Broken Rail Brewing.

[1] Minimum changes were made to exterior with upgrades to interior to support the functioning brewing operations.

[4] The Grand Trunk Railway was extended west to Sarnia in 1859 and south to London in 1860, with the two branches meeting at St. Marys station.

[4] Media related to St. Marys Junction Railway Station at Wikimedia Commons