St. Monica's Senior High School is a girls' second-cycle institution in Mampong in the Ashanti Region of Ghana.

The school's history is traced to Rt Rev John Orfeur Aglionby, the Anglican Bishop of the Gold Coast whose missionary work birthed the Convent of Our Lady and Saint Monica.

In 1926, the bishop invited the sisters of the Order of the Holy Paraclete (England) to set up a school for girl-child education.

In 1946, St Monica's Secondary School in Mampong was established as a separate institution from the Teacher Training College.

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