It was founded in 1708, becoming the ninth church of its denomination established in Delaware with the help of the Society for the Propagation of the Gospel in Foreign Parts.
Members of the Church of England settled in the area from around 1680, meeting in homes and later the courthouse.
They petitioned the Bishop of London to send clergy to serve them and other churches in Sussex County; the first missionary arrived in 1708, but stayed for only a year.
In 1773 the church was presented a silver communion service made by John David, Silversmith of Philadelphia.
John Marshall Phillips, Curator at Yale University, wrote that the Chippendale Period communion service was "outstanding" and "the finest silver in Delaware."
Plans were purchased from a Philadelphia architect and on 27 May 1854, the Right Reverend Alfred Lee, Bishop of Delaware laid the cornerstone of the present building.