The first Chaldean Catholic Assyrian people to immigrate to the United States arrived at the end of the nineteenth century.

In September 2020 the cathedral was vandalized with graffiti of contradictory messages including among other things pentagrams, upside down crosses, white power, swastikas, "BLM", and "Biden 2020".

In 2014, the cathedral hosted a fundraising event with the Mar Toma Council that raised $650,000 for Christian refugees impacted by conflicts in Mosul and the Nineveh Plains.

These efforts were part of broader activities to support displaced communities in Iraq, Turkey, Syria, and Lebanon.

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