The church is located in the heart of Watertown's Armenian community, the largest on the East Coast of the United States.

Its jurisdiction falls under the Armenian Prelacy of the Eastern United States, based in New York City, and the Holy See of Cilicia (Lebanon).

[1] The community was established in 1933, meeting in a rented church in Boston, but when the owners of the building decided to sell it, committees were established to seek out new facilities.

Groundbreaking took place on June 6, 1956, and the new church was consecrated on October 20, 1957 by Archbishop (Later Catholicos) Khoren I Paroian.

[4] The church has faced tensions during the 2023 Azerbaijani offensive in Nagorno-Karabakh.