St. Stephen's Episcopal Pro-Cathedral is an Episcopal church located in Wilkes-Barre, Luzerne County, Pennsylvania.

It is the Pro-Cathedral in the Diocese of Bethlehem.

The Cathedral Church of the Nativity in Bethlehem, Pennsylvania serves as the primary cathedral of the diocese.

The present church building is the fifth one for the parish.

Philadelphia architect Charles M. Burns designed the church in the Romanesque Revival style.