[2] The hospital was located on St. Vincent's Lane north of St. Charles Rock Road; it is the current home of the Castle Park Apartments.

It opened in August 1858 at Ninth and Marion Streets in St. Louis with four patients and fifteen sisters.

In 1895, the home relocated to St. Vincent's Lane (the current Castle Park Drive), up a hilltop from the Rock Road in St. Louis County.

This massive, castle-like building is listed on the National Register of Historic Places.

By 1941, the home was operated by the Daughters of Charity of St. Vincent de Paul for the treatment of mental and nervous disorders as well as selected cases of alcoholism and drug addiction.