It was designed by a local architect, James H. Hutchisson, in the Gothic Revival style.

It replaced an earlier frame structure that had been completed in 1847 and burned prior to the erection of this building.

The neighboring Black parish, St. Peter Claver, was established in 1911.

A new St. Vincent de Paul Parish was then established in western Mobile County to serve the Tillmans Corner area.

The original church was placed on the National Register of Historic Places on April 24, 1992, as a part of the Historic Roman Catholic Properties in Mobile Multiple Property Submission.