The church dates from medieval times but the current building is mainly the result of a rebuilding project in the 18th century carried out by one of the owners of the hall, the Earl of Hardwicke.
The Earl's architect was Henry Flitcroft, who demolished the medieval church on the site apart from the north chapel (sometimes known as the Chicheley Chantry), which was incorporated in the new building.
A stained-glass window commemorates Thomas Agar-Robartes, one of a number of MPs who were killed in World War I, and his mother Mary, Viscountess Clifton.
In the graveyard is a monument to Elsie Bambridge, the daughter of Rudyard Kipling, who left Wimpole Hall to the National Trust.
When it was inspected for the National Pipe Organ Register in the 1980s, it was not possible to date the case, but it contained a 19th-century Brindley & Foster instrument "in a dreadful state".