The west end of the nave was rebuilt in the early 16th century which included the replacement of a small tower with a bell-turret.

[2][6] In 1605, a new church dedicated to St Mary's was built on a more centralised site near Melcombe Regis' harbourside.

Furthermore, it was considered that Melcombe Regis was "subject to the incursion of foreign enemies, who might surprise the town during Divine service, and depart before the inhabitants could repair home to make resistance".

The external walls and roof of the church were extensively repaired, the interior cleaned and recoloured, and some new fittings added.

[9] A daughter church, St Aldhelm's, was built in 1939–41 to serve the growing population of Radipole.

[10] The vestry of St Ann's was rebuilt in 1960, with its doorway incorporating stonework from a 17th-century house in Weymouth which was demolished the previous year.

[6][2] The church room opposite St Ann's was built as a schoolroom in 1850 on a plot of land donated by William Eliot.