St Cecilia's College is a secondary school located in Derry, Northern Ireland.

It is a Catholic-maintained girls' school with an enrolment of 947 pupils aged 11–18 and is located in the Creggan area of Derry.

The college decanted to the Northland Road to facilitate the construction of a new building which opened for the start of term in September 2010.

In March 2001 a programme for the extension and refurbishment of the college was announced under public-private partnership arrangements.

St Cecilia's College's motto is 'Aspire, Endeavour, Achieve.'