It links South Parks Road to the north and Longwall Street to the south, where it also meets Holywell Street.
[1] The road is named after St Cross Church.
[2] Linacre College, one of the colleges in the University of Oxford, is located at the northern end, opposite the Tinbergen Building, used by the university's Department of Zoology and Department of Experimental Psychology.
St Catherine's College, another Oxford University college, is in Manor Road, a cul de sac east off St Cross Road.
Holywell Manor, St Cross Church, Holywell Cemetery, and Jowett Walk are at the southern end.