St. Louise's Comprehensive College (Irish: Colaiste Naoimh Labhaoise) is a comprehensive high school located in the Upper Falls Road, Belfast.

The religious order the Daughters of Charity of St Vincent de Paul was asked by the Catholic Church to take responsibility for this school.

[3] It offers technical and vocational courses alongside a large suite of academic subjects.

In 2006 it was recognised as one of the first Specialist Colleges in Northern Ireland with particular expertise in Performing Arts and Media.

At ‘A’Level, its value added scores have placed it in the top ten percent of schools across Britain for several years in succession.