It was managed by Tees, Esk and Wear Valleys NHS Foundation Trust.

The facility, which initially absorbed patients from the aging North Riding Asylum in York, was designed by Charles Henry Howell using a compact arrow layout.

[2] It joined the National Health Service as St Luke's Hospital in 1948.

[3] In November 1980 the regional medium-secure psychiatric unit was established in a modern building to the rear of the hospital called the Hutton Centre.

[4][5] St Luke's was demolished in 2010[2] to make way for the new Roseberry Park Hospital.