[2] St Mark's was founded by the Reverend Charles Tooth as a centre of worship for Anglo-Catholic members of the Anglican Church in Florence.
He started a house church at 1 Via dei Serragli in 1877 to teach Anglo-Catholic principles and celebrate the Eucharist daily during the week.
[6] The church was damaged by the 1966 flood of the Arno, resulting in the loss of George Frederick Bodley's 19th-century stencil work on the lower walls, although some survived behind a display cabinet.
The building was altered by Tooth, who turned the ground floor into a church with nave, aisles, transept and chancel, about 90 feet (27 m) long[3] and seating 400.
[2] The interior is decorated in the Pre-Raphaelite style and the upper reaches of the church have floral motifs which the art historian Berenice Schreiner has described as having "a wonderful sense of naturalism".