[1][2] The parish has connections with the persecution of the Lollards in the early 1500s when a group of locals known as the Amersham Martyrs were burned at the stake on the hill overlooking the old town.

In 1553, Scottish reformer John Knox preached his last sermon at Amersham before going into exile to flee the wrath of Queen Mary.

Edward Drake, who commissioned a major restoration of the church in 1890, and the external appearance dates from this time.

[8] The Church of England parish of Amersham is part of the Archdeaconry of Buckingham in the Diocese of Oxford.

[9] The body of the murderer Ruth Ellis was reburied in the churchyard extension of St Mary's Church.