It contains a guest appearance from American rapper Shawnna, who provides a call and response dichotomy with Ludacris for the song's chorus.

Production was handled by then-unknown Roc-A-Fella Records producer Kanye West, while co-production was helmed by Ludacris himself, both of whom wrote the song.

"Stand Up" topped the R&B/Hip-Hop singles for four weeks, and received a Grammy Award nomination for Best Rap Solo Performance.

Ludacris raps at a night club with many bizarre elements, such as a huge beer bottle, which he drinks from, a giant sneaker that he later wears, disabled people in wheelchairs dancing, a woman whose behind grows to a humungous proportion after kissing Luda, Luda and another woman as toddlers, and much more, with scenes mostly alluding to the song's lyrics.

Chingy, Katt Williams, 2 Chainz, Scooter Braun, Kanye West (the song's producer), Tyra Banks & Lauren London made cameo appearances on the video.