He obtained a Master of Science degree from the Institut Cochin and a PhD in Genetics from Necker in 1992.
[1] Lyonnet has been a member of the board of the European Society of Human Genetics and its scientific program committee.
[1] In 2007, he created the Laboratoire International Associé Franco-Marocain of Genetics, co-directed by Professor Abdelaziz Sefiani of the University of Rabat Medical School in Morocco.
This group is a founding member of the Imagine Foundation (Institut des Maladies Génétiques).
His research team at Imagine focuses on forms of neurocristopathy and fetal syndromes that result from abnormal development of primary cilium and planar polarity.