The formation of this cell population therefore requires a timely and spatially controlled interplay of inter- and intra-cellular signals.
An alteration in the occurrence and timing of these signals leads to a set of syndromes called Neurocristopathies (NCP), which comprises a broad spectrum of congenital malformations affecting an appreciable percentage of newborns.
[6] This new criteria takes into account the axial origin of the NC population that contributes to the derived tissue affected in a particular NCP.
According to this, some diseases have a single axial origin, i.e., they arise from an alteration in the development of only one NC population (e.g. cranial NCP, such as Auriculo Condylar Syndrome).
[7] The usefulness of the definition resides in its ability to refer to a potentially common etiological factor for certain neoplasms and/or congenital malformation associations that are otherwise difficult to group with other means of nosology.