The network's scheduling varied with each version, ranging from traditional entertainment programming, including television series, sitcoms and films.

During the first years of the launch, Fox Life had a varied programming grid that consisted of soap operas, comedies, dramas, films and cooking shows, which was considered the counterpart of the FX channel with aim of attracting a female audience.

[1] By then, the channel's programming was made up of series and films aimed at young and adult audiences, with productions that stood out in the leading roles.

[2][3] On January 10, 2022, it was announced that the Latin American version of Star Life would be shut down on March 31 along with several other networks in the region.

When the current format was launched, it was with the exception of Brazil, where the channel aired, from 8 a.m. to 7 p.m., content from Utilisima and original shows for the local audience, as Bem Simples, and, from 7 p.m. to 8 a.m., reality series seen on the Fox Life service elsewhere in the region (most non-original cooking shows are not seen on the Brazilian service since the rights are held by GNT).