There it turns northeasterly along the west bank of Grassy Creek, which lies inside Virginia and forms the line between Buchanan and Dickenson Counties, in order to avoid the deep gorge through Breaks Interstate Park.

It runs south through Camp Branch Gap, and then continues in a general southerly direction alongside small creeks and over two summits to State Route 83 east of Haysi.

The fork ends as the road approaches Sandy Ridge and the Tennessee Valley Divide, which it climbs Big A Mountain via a series of hairpin curves.

SR 80 again runs cross-country past Rockdell, where it begins to climb Clinch Mountain, which it crosses (into Washington County) at Hayters Gap.

It continues to follow Logan Creek past Yellow Springs and Giesley Mill, then crossing a low summit to Meadow View.

SR 80 crosses Interstate 81 at a Diamond interchange southeast of Meadowview, providing access on I-81, and then ends at U.S. Route 11 at Cedarville.