It then goes through downtown and junctions with SR 456, a short cut to Oneida, before leaving Huntsville.

They then enter Jacksboro and becomes the major artery of the city, bypassing downtown to the west and running through the heart of the main business district.

SR 63 then leaves LaFollette and travels up the Powell Valley through the communities of Fincastle, Well Springs, Speedwell, Powell Valley and Arthur before entering Harrogate, crossing into Claiborne County in between Fincastle and Speedwell.

[3][5] In Harrogate, SR 63 passes by the Lincoln Memorial University (LMU) campus then has an intersection and short concurrency with US 25E/SR 32.

It then becomes a very curvy secondary route and continues east through a mix of farmland and mountainous terrain to pass through the communities of Forge Ridge and Hopewell before crossing the Powell River and having a junction with SR 345 and crossing into Hancock County.