SR 456 begins at an intersection with SR 63/SR 297 just east of Huntsville, where the road continues south into Winona as Winona Road.

The highway then turns left onto Paint Rock Road begins to head into mountainous terrain as it goes northwest through a narrow and long valley.

It passes through the community of Paint Rock before winding its way northwest through mountains to enter Oneida.

SR 456 passes by several businesses and homes before crossing a bridge over a railroad track and entering downtown.

It heads west as Depot Street along the south side of downtown before coming to an end at an intersection with US 27/SR 29, just feet from that highway's intersection with SR 297.