The ancient sources say little of her family; however, Suetonius states that she was a great-great-granddaughter of Titus Statilius Taurus, a Roman general who was awarded a triumph for his victory and was twice consul.

[2] Her grandmother might have been Valeria Messalina Corvina, one of the daughters of Roman senator Marcus Valerius Messalla Corvinus who served as consul in 31 BC.

Her fourth husband was the consul Marcus Julius Vestinus Atticus to whom she may have borne a son (who died in 88 AD).

After the death of the emperor's second wife Poppaea Sabina, Vestinus was forced to commit suicide in 66, so Nero could marry Statilia.

After Nero's death, Otho promised that he would marry her, before his suicide in 69 AD.