Several plot points connect to parent series Grey's Anatomy through fictional crossover events.

While rescuing a man from the helicopter, the team revolts against Beckett, who makes Herrera the captain for the mission.

[26] Krista Vernoff returned as showrunner as part of a two-year deal with ABC.

[27] During the writing process for the season, an episode was written where a character used a racial slur multiple times, which led to a pause of the writers room.

[22] As a result, Zoanne Clack was named head writer and executive producer, replacing Kiley Donovan.

[22] Josh Randall and Merle Dandridge were upped to series regulars after recurring the previous season.

Pat Healy was also upped to a series regular after recurring the past several seasons.

[24] When the 2022–23 United States network television schedule was announced, Station 19 would remain on Thursdays at 8:00 PM.