It was built on land leased from McGill University on its Macdonald Campus, in close proximity to major rail lines and roads.

[2] In order to comply with provincial standards for long-term care facilities, renovations were undertaken in 2003, which resulted in the construction of a thermal power plant and electrical substation, as well as a new building, the 116-bed Remembrance Pavilion to accommodate patients with cognitive impairment.

[2] On April 27, 2012, Veterans Affairs Canada and the Government of Quebec signed an agreement to transfer the hospital to provincial jurisdiction.

Anne's Hospital would become geriatrics centre, and would be an autonomous entity reporting to the Montreal Health and Social Services Agency.

[4] In February 2021, a $19 million settlement was reached in a class action lawsuit alleging that the quality of care was degraded after the transfer to provincial jurisdictions.