[2][3] When he was young, Lusignan joined the Dominican Order and studied under an Armenian bishop named Ioulianos.
By 1562 he was a priest and worked under two Latin bishops of Limassol, Andrea Mocenigo and Serafim Fortibraccia.
In 1571, Cyprus fell to the Ottoman Empire, and after that, Lusignan spent much of his time collecting ransom money to buy the freedom of relations who had been captured.
In 1575 he moved to Padua, under the control of the Republic of Venice, and there he designed a famous map to supplement his book, dedicating it to the last Latin Archbishop of Cyprus, Filippo Mocenigo.
[4] His Chorograffia and his Description de toute l'isle de Cypre include many classical sources such as Strabo, Pliny, Virgil, Ovid, Pausanias, Plutarch, Diogenes Laertius and reference various ancient cities like Salamis, Kourion and Amathus and important mythological figures of Cyprus such as Cinyras, Aphrodite and Adonis.