Stenocereus zopilotensis is a tree-like cactus that grows with candelabra-shaped branches, reaching heights of 4 to 5 meters.

The shoots are parallel and ascending, light green in color, with diameters ranging from 6 to 11 centimeters, and typically do not branch further.

It has one to three central spines that are initially white but turn gray over time, measuring up to 1 centimeter long.

The cactus produces whitish-green flowers that bloom at night, located at the tips of the shoots.

[1] Stenocereus zopilotensis is commonly found in the Mexican state of Guerrero, particularly in the Cañon del Zopilote, within deciduous forests at elevations between 200 and 750 meters.