[1][2] Syjuco works in photography, sculpture, and installation, moving from handmade and craft-inspired mediums to digital editing and archive excavations.

Recently, she has focused on how photography and image-based processes are implicated in the construction of racialized, exclusionary narratives of American history and citizenship.

[3] Her early artwork explored the friction between the authentic and the counterfeit, addressing political concerns regarding issues of labor and economies within the capitalist system.

In September 2019 Syjuco opened a large solo exhibition titled Rogue States at the Contemporary Art Museum St.

[15][16] In 2024 Syjuco opened After/Images, a large-scale exhibit with an focus on photography and videography of Filipinos to showcase the impacts of colonialism through the framing and existence of the visual medium.