She married three times; firstly to Humphrey III of Toron, secondly to Miles of Plancy; her third and last husband was Raynald of Chatillon.
Through Stephanie, Raynald succeeded as lord jure uxoris of the lordship of Oultrejordain, and used his new position to harass Muslim caravan and pilgrimage routes; in 1183 he even threatened to attack Mecca itself.
The Old French Continuation of William of Tyre claimed that Stephanie hated Isabella's mother Maria Comnena, and prevented her having any contact with her daughter.
This was probably for political reasons: Baldwin had arranged the marriage to remove the little girl from the influence of her stepfather's family, the Ibelins.
Raynald continued to harass the caravan and pilgrimage routes, leading to the invasion of the kingdom by Saladin in 1187.