Stephen L. Hoffman (born July 31, 1948) is an American physician-scientist, tropical medicine specialist and vaccinologist, who is the founder and chief executive and scientific officer of Sanaria Inc., a company dedicated to developing PfSPZ vaccines to prevent malaria.

Hoffman was raised initially in Belmar and subsequently in Ocean Township, Monmouth County, New Jersey.

[6][5] After completing his residency in 1978, Hoffman was co-founder and director of the Tropical Medicine and Travelers clinic at University Hospital, University of California, San Diego, an adjunct clinical faculty member, and an emergency room physician.

Hoffman worked with utilizing human genomics and proteomics to develop immunotherapies and vaccines against cancer and to establish the potential for the field of personalized medicine.

Hoffman is married to B. Kim Lee Sim, PhD, a molecular biologist, who is the founder and president of Protein Potential LLC and executive vice president of Sanaria Inc.[45] They have three children (Alexander [JD],[46] Seth [MD],[47] and Benjamin [MD, PhD][48]).