Strange later faces several problems from the newly-established multiverse, including a rift between realities created by an interrupted attempt to erase everyone's knowledge of Peter Parker's secret identity as Spider-Man which had been caused by Mysterio; and a Darkhold-corrupted Wanda Maximoff, whom he must stop from acquiring America Chavez's ability to traverse the multiverse for her own goals.

Feige, a self-professed "fanboy", envisioned creating a shared universe just as creators Stan Lee and Jack Kirby had done with their comic books in the early 1960s.

The film began principal photography in November 2015 in Nepal, before moving to the United Kingdom and Hong Kong, and concluding in New York City in April 2016.

Strange is a neurosurgeon who, after a car crash that led to a journey of healing, discovers the hidden world of magic and alternate dimensions.

[8] The film's mysticism resonated with Cumberbatch, for whom spirituality has been important since he spent his gap year teaching English at a Tibetan Buddhist monastery in Darjeeling, India.

[11][12] Cumberbatch took great care in defining the physical movements and gestures for the spells, knowing that they would be noted and studied by fans.

[16] Markus and McFeely described Strange in Infinity War as "[ending] up being the reasonable adult in the room" with the "widest perspective available".

[36] In 2016, Strange is a wealthy, acclaimed but arrogant neurosurgeon, who severely injures his hands in a car crash while en route to a dinner, leaving him unable to operate.

Fellow surgeon and former lover Christine Palmer tries to help him move on, but Strange ignores her attempts and vainly pursues experimental surgeries to heal his hands, at the cost of his wealth.

Strange learns about Jonathan Pangborn, a paraplegic, who he had refused to treat earlier due to perceiving him having little chance of recovery but had mysteriously regained use of his legs.

Pangborn directs Strange to Kamar-Taj, where he is rescued from a band of thieves attempting to steal an expensive watch of his and taken in by Mordo, a sorcerer under the Ancient One.

She reluctantly agrees to train Strange, whose arrogance and ambition remind her of renegade sorcerer Kaecilius, who had recently stolen pages out of a vital book from the Kamar-Taj library.

Strange learns that Earth is protected from threats from other dimensions by a shield generated from three buildings called Sanctums, in New York City, London, and Hong Kong, which are all connected and accessible from Kamar-Taj.

Strange uses his impressive memory and progresses quickly, secretly reading the text from which Kaecilius stole pages, learning to bend time with the mystical Eye of Agamotto.

Mordo and Wong catch Strange in the act and warn him against breaking the laws of nature, drawing a comparison to Kaecilius' desire for eternal life.

Before dying, she tells Strange that he too will have to bend the rules to complement Mordo's steadfast nature to defeat Kaecilius, in addition to making him choose between healing like Pangborn or serving protecting the Earth.

Strange and Mordo arrive in Hong Kong to find Wong dead, the Sanctum destroyed, and the Dark Dimension engulfing Earth.

Twelve hours later, he is inadvertently released by Leeds (who had Strange's sling ring with him) and witnesses Parker and his alternate selves curing the villains.

Strange tells Maximoff that he is not there to talk about the Westview incident but about Chavez, however, she accidentally reveals she already knew of her and intends on using her to take her power to be with alternate real versions of her children Billy and Tommy.

Another alternate version of Strange appears in the animated series Your Friendly Neighborhood Spider-Man, voiced by Robin Atkin Downes.

After being appointed the title of Sorcerer Supreme, the newly dubbed Doctor Strange Supreme had then proceeded to make countless attempts to reverse Palmer's death using the Eye of Agamotto, but fails no matter what he tries and is informed by the Ancient One that the event was an irreversible "absolute point" in time, as her death drove him to become a sorcerer, the resulting paradox would damage the fabric of reality.

As his universe collapses, Strange Supreme helplessly watches as Palmer fades away from existence and he grieves alone in a pocket dimension he creates.

Strange materializes a bar and meets Captain Carter, Star-Lord T'Challa, Thor, Gamora, and Erik "Killmonger" Stevens, who had been chosen by the Watcher as the Guardians of the Multiverse to combat Ultron.

Sometime later, Strange abandoned his post and opened a portal to another universe finding a Mohawk tribeswoman Kahhori and Sky World people in Queen Isabella of Spain's courtroom, saying that he had been looking for her for a long time.

He brought Carter with him to his Sanctum and revealed he had captured several "universe-killers" such as a Thanos and a young Peter Quill to protect the Multiverse.

Kahhori eventually succeeded in returning everyone home, but not before Hela, Hulk, another Thor, and Xu Wenwu gave their weapons and symbols of power to the two women.

In an unnamed alternate reality, Strange protects America Chavez from an interdimensional demon who is attempting to steal her ability to enter the multiverse.

Upon Strange's demise, the Illuminati lied to the world by telling them that he sacrificed himself to kill Thanos, and a statue was erected in his honor at the New York Sanctum, bestowing him the title of "Earth's Mightiest Hero".

In an alternate reality, Strange grew depressed and used the Darkhold to dreamwalk and find other versions of himself who might be happily living with their Christine Palmer.

[37] An alternate, unseen version of Strange found himself in the Void, a wasteland-like realm to which everything "pruned" by the Time Variance Authority was sent, and was killed by Cassandra Nova, Charles Xavier's twin sister and self-styled ruler of the Void, who wore his severed skin for four days and kept his sling ring with two Infinity Stones as a memento, which she later uses to help Wade Wilson and Logan escape from Alioth.