After a stint at Warner Bros. managing the production of mobile games, she began working at various companies in business development and sales.

[11][12] After a few months of competing and making a name for herself, Case traveled to Dallas on a pilgrimage to meet some of the developers of her favorite first-person-shooter computer games.

[2]: 186  After Romero put up a web page jokingly insulting her skill at the game, Case publicly demanded a rematch with him.

[13] While Case initially struggled in the best-of-three rematch, she rallied back to win the first round 25–19, and went on to ultimately defeat Romero.

[1][15] Case was twenty years old at the time she won the rematch in 1997,[16]: 104  and beating one of the co-creators of Quake at his own game brought her a lot of publicity.

She gained a sponsor in computer mouse manufacturer SpaceTec IMC that year,[13][17][5][18] and her victory against Romero received coverage in Rolling Stone.

[21][26] Between 1998 and 2000, Case authored three strategy guide books for Prima Games: Jazz Jackrabbit 2 (1998), Buck Bumble (1998), and Daikatana (2000).

[21][25] After numerous members of the Daikatana development team left during the game's troubled production, Case accepted Romero's job offer to become a level designer in November 1998.

According to David Kushner's Masters of Doom, it was at this point when Case "radically reinvented herself" by losing weight, bleaching her hair, and undergoing breast augmentation surgery.

[36] Case left Ion Storm in January 2001[37] to follow Romero to his new company, Monkeystone Games, which was founded in August 2001.

[39] Case worked as a producer for Monkeystone's first game, Hyperspace Delivery Boy!, and also created the music and sound effects.

According to Case, she decided at this point to slowly transition out of working in the game development industry, stating in an interview: There was a ton of harassment and hate and sexism and abuse.

[43] Case recalled receiving the opportunity to leave game development when one of her contacts approached her about a potential junior sales position at his workplace.

[45][46] Case also served as Senior Director of Business Development at Live Gamer,[47][48] and joined PlaySpan in 2010 as vice president of sales.

After working as the vice president of growth at San Francisco-based startup Layer,[43][53] in 2022 Case became the Chief Revenue Officer at computer security firm Vanta.

[56] Case dated Quake player Tom "Entropy" Kimzey, who was also a University of Kansas student and a member of Impulse 9.