This upsets Stewie, and he ultimately appears to murder Lois while she is on the cruise, only to find out that she had survived the attack as the year passes.

Stewie is also upset at not being invited on the cruise simply for being the baby, and he concocts a plan to embarrass Lois upon her return.

Throughout the next year, Peter begins dating women again (including a cancer patient, a stick figure, and even Bonnie) but talks Joe into posing as Lois occasionally so that her death does not emotionally scar Chris.

Everyone in the courtroom is in disbelief that Stewie would try to murder Lois, but she insists that he is evil, and explains what happened to her a year earlier: after falling overboard, she was rescued by a reverse merman.

He ties up his family when they return home, murders Cleveland when he drops by, and kidnaps Brian, forcing him to drive him to the CIA in Langley Falls, Virginia, where he gains access to a supercomputer and takes control of the global power grid.

The CIA submits to his demands, and Stewie becomes "President of the World" after encountering Stan Smith and Avery Bullock from American Dad!

Upon his rise to power, Stewie implements harsh, cruel and unusual laws and policies, including banning direct-to-video Disney films, requiring everyone to throw apples at Peter, making sexual intercourse illegal and punishable by death (Quagmire turns to origami), requiring all milk to be sourced from Hilary Swank's breasts, and creating concentration camps holding people imprisoned for ridiculous crimes.

Lois eventually gains the upper hand and prepares to kill Stewie, but cannot bring herself to murder her own child.

Stewie takes the opportunity to kill her, but before he can, he is shot dead by Peter (who uses a one-liner from Lethal Weapon 2 which Brian comments did not fit the context of the situation).

Brian enters Stewie's room with postcards from Peter and Lois enjoying their cruise, only to find Stewie emerging from a computer simulation device he had built to see what would happen if he killed Lois and took over the world; he concludes that he is not yet ready for that, causing Brian to wonder if the events of the episode were ultimately a "dream sequence" which may be essentially a giant middle finger to hypothetical external viewers.

[3] "Lois Kills Stewie" was written by recurring voice actor and future showrunner Steve Callaghan, and directed by Greg Colton.

[7] "Stewie Kills Lois" and "Lois Kills Stewie", along with the final five episodes of the fifth season and the first seven episodes of the sixth season, were also released on DVD under the title "Volume 6" by 20th Century Fox in the United States and Canada on October 21, 2008, five months after they had completed broadcast on television.

[12] In addition to the main cast, actors Patrick Stewart and Phil LaMarr, and American Idol judges Simon Cowell, Randy Jackson and Paula Abdul guest starred in the episode.

[13][14] The episode also featured the recurring voices of actress Jennifer Tilly and Patrick Warburton, and writers Danny Smith and John Viener in minor appearances.

Since they're both Trekkies, Seth MacFarlane and David A. Goodman had wanted to use the cliffhanger music from "The Best of Both Worlds" if they ever got up to 100 episodes of Family Guy.

[13] Stewie is seen auditioning for American Idol in a cutaway, singing "Lost in Your Eyes" before judges Simon Cowell, Randy Jackson and Paula Abdul, who all vote him out.

[5] This crossover is extended on the Volume 6 DVD when, before the confrontation, Brian and Stewie first bump into Stan and Bullock in the restroom.

"Stewie Kills Lois" features the recurring gag of the Kool-Aid Man bursting through the courtroom wall at an inopportune time, exclaiming "Oh yeah!"

This time, the judge implores the people of the court to please stop saying "Oh no!," because, as he puts it, "The damn Kool-Aid Man is gonna keep showing up!"

Stewie fulfills his series-long fantasy of killing his mother, and does so with the type of callous violence that you'd expect for this implausible scenario.

For the disturbed fans waiting for some form of a matricidal manifestation, you can feel comfort knowing, without spoiling too much, that the youngest Griffin absolutely means business and ensures that he doesn't fail this time around.

[...] There are some tense courtroom moments, a birthday celebration with the gift of Lionel Richie, a cruise ship, machine guns, and the reappearance of the Kool Aid Man that help round out this carefully crafted and well-told cohesive storyline.

With the amount of cheap manatee jokes kept to a reasonable level, this episode also manages to find an excellent balance between comedy and storytelling.