The Strada statale 115 Sud Occidentale Sicula (SS115) is an Italian state highway 395.7 kilometres (245.9 mi) long in Italy located in the regions of Sicily.

It is one of the major roads in Sicily.

It is the major state highway running along the south coast and connects the towns of Trapani and Syracuse via Agrigento and Ragusa.

It is a part of the European route E45 and European route E931.

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