Upon death, upgrades will be lost and levels will be re-arranged once more, but the player may be able to access teleporters to unlocked stages from the hub spacecraft.

From the hub spacecraft, the player chooses a primary weapon at the beginning of each run from a shotgun, a machine gun or a railgun.

[2] A variety of weapons can be picked up within the levels when dropped from enemies, which generally have limited ammo and can be thrown when empty for additional damage.

Players are rewarded for playing the campaign with tokens that can be used to unlock 25 "modifiers" that can be activated at the start of a run to significantly alter the gameplay.

The Millennium Edition was released on October 2, 2017, and added mutators, challenge modes, the ability to save runs, and additional campaign content.

[7] The Gold Edition was released on May 9, 2020, and added a New Game Plus mode, as well as a long list of bug fixes, balance tweaks, and optimizations.