This is S2 Games' second MOBA game aimed to a more casual player base than Heroes of Newerth, most notably incorporating various gameplay elements that focus on heavily reducing player toxicity and introducing persistent mechanics outside of the arena, including Pets and Crafting.

The goal of the game is to destroy the central structure of the opposite base, called the "Crux".

[1] As of October 2018[update] Strife servers have been shut down without comment from developers with S2 Games being quietly closed down.

MMOs.com's review describes Strife as a game that "blends traditional MOBA elements with unique features to create an original gameplay experience".

Esportsedition's review puts forward the idea that "There’s no hope for Strife to make a comeback—it is, indeed, a very dead game—but that doesn’t diminish the actual quality of gameplay"[11] The same review also discusses the relation of release dates of both Strife and Heroes of the Storm, a "casual MOBA" video game developed and published by Blizzard Inc.