The school was founded by Father Michael Kenelley, S.J.,[8][9] on June 21, 1960, in what was then the undeveloped, west side of Houston.

[10] In 1971, the school asked to declare Chapter 10 bankruptcy as it lost money in the Sharpstown scandal.

[11] The school surrendered seven acres of its original property to pay its debts and emerge from bankruptcy protection.

An additional 410 were temporarily enrolled at Strake after the hurricane for a period of time from Jesuit High School in New Orleans.

[14] The league began in 1935 under the direction of Albert Mitchell (then principal of Central Catholic, San Antonio).

), the public school athletic league, partly due to the efforts of Joe Nixon, a member of the Texas House of Representatives.

The "Fighting Crusaders" athletic department provides 14 different programs which include: baseball, basketball, cross-country, football, golf, ice hockey, lacrosse, rugby, soccer, swimming & diving, tennis, track & field, water polo, and wrestling.

[14] Despite moving to the U.I.L., Strake Jesuit had a storied rivalry with Saint Thomas High School (STH).