Straub Benioff Medical Center is not-for-profit health care system with a 159-bed hospital in Honolulu, and a network of neighborhood clinics.

In the latter part of 1920, Howard Clarke resigned his commission in the United States Army and joined as a specialist in Eye, Ear, Nose and Throat.

[5] Its burn unit, constructed in the 1980s, is the only facility of its kind in Hawaii, and the only one in the North Pacific region between California and Asia.

It regularly takes patients from other Hawaiian islands, other Pacific nations and territories, and cargo ships at sea.

It took nine patients from Maui who had been injured in the 2023 Hawaii wildfires, the largest mass casualty even in the hospital's history.