One night, Ken's friend Cho appears at the dojo in a panic, revealing that he has learned of M. Bison's organization, Shadaloo, and its current agenda—vicious human experiments revolving around a drug called Doll which effectively brainwashes people, usually for acts of violence.

Ryu, now a more capable fighter, has also emerged on Shad and entered the tournament, while befriending Cho's old girlfriend Po-Lin and her little brother Wong-Mei, who have been recently orphaned and manage their family's Chinese restaurant.

As the fighting progresses over the course of a few days, Ryu, Guile, and Chun-Li advance, facing opponents such as Blanka, E. Honda, Dhalsim, and Zangief some of whom have personal goals of their own.

Eventually, a weary Chun-Li begins to recall the advice she's received from her father and Ryu respectively, regains control of herself, and surprises Vega with a powerful Kikoken a moment before he can land the finishing strike.

After overcoming Sagat, Ken is set to fight in the next day's final match, but soon confronts Bison backstage in a hallway, seeking to take his anger out on him immediately.

The Street Fighter II manga was originally collected in three tankōbon editions in Japan published by Tokuman Shoten following its serialization in Family Computer Magazine.

Udon has published a revised adaptation of the complete manga, featuring the original uncensored black and white artwork and right-to-left orientation, as a three-volume set.