Streptothricins are a group of antibiotics in the aminoglycoside class.

[1] The first antibiotic in the group was isolated from Streptomyces lavendulae in 1942.

[2] It was later determined to be a mixture of closely-related compounds, and is now known as nourseothricin.

Although initial interest was positive because it appeared to be the first broad-spectrum antibiotic, meaning it was effective against both Gram-positive and Gram-negative bacteria, it never found clinical use due to toxicity.

[3] However, because of the increasing need for new antibiotics due to resistance to existing antibiotics, there is a current interest in developing new drugs based on the chemical scaffold of the streptothricins.