Over his four decades of affiliation with Penn State University, he added thousands of specimens to the entomological research collection.

From an early age, Frost was interested in natural history, spending much of his free time exploring the New York scenery around him.

[2] He would fastidiously record his observations of the flora and fauna he encountered, occasionally bringing different species home for experimentation.

Following his retirement from Penn State University, Frost moved to Florida and utilized his light traps to collect over 400,000 specimens at the Archbold Biological Station until 1971.

He then returned to Penn State to volunteer at the Frost Entomological Museum, identifying insects and working on publications until his death on January 21, 1980.