Sturisomatichthys leightoni is a species of armored catfish of the family Loricariidae endemic to Colombia, where it occurs in the upper Magdalena and Cauca River basins.

This species grows to a length of 18 centimetres (7.1 in) SL.

The male Sturisomatichthys leightoni is shorter than the female one and has a short beard (1–2 mm).

The male fans fresh water on top of the eggs until the babies hatch.

The catfish is named in honor of Sir Bryan Leighton (1868-1919), who presented the type specimen to the British Museum.