Substituted phenylmorpholine

Substituted phenylmorpholines, or substituted phenmetrazines alternatively, are chemical derivatives of 2-phenylmorpholine or of the psychostimulant drug phenmetrazine.

Most such compounds act as releasers of monoamine neurotransmitters, and have stimulant effects.

Some also act as agonists at serotonin receptors, and compounds with an N-propyl substitution act as dopamine receptor agonists.

Some compounds have also become subject to illicit use as designer drugs.

[1][2][3][4] Additional phenylmorpholines and their activities as monoamine releasing agents (MRAs) have been described.

Various phenmetrazine derivatives
The 2S,3S isomer of phendimetrazine ( i.e. (2S,3S)-3,4-dimethyl-2-phenylmorpholine)
The (+)-enantiomer & (−)-enantiomer of pseudophenmetrazine .